In a study comparing 16 patients with mild traumatic brain injury (TBI) with 20 normal controls, NeuroQuant® and NeuroGage® showed high test-retest reliability, rendering it a reliable and valid method for assessing the anatomic effects of TBI.  The study also showed that progression of atrophy may continue for years after injury, even in patients with mild TBI.  The study further showed that progressive brain atrophy in patients with mild TBI was associated with inability to return to work. 

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Ross, DE, AL Ochs, JM Seabaugh, MF DeMark, C. R. Shrader, J. H. Marwitz, M. D. Havranek (2012). Progressive brain atrophy in patients with chronic neuropsychiatric symptoms after mild traumatic brain injury: A preliminary study. Brain Injury 26:1500-9.  To view the PubMed citation of this paper, click here.