This report describes the case of a 57-year old man who was in an accident in which his vehicle was rear-ended by a tractor-trailer, leading to traumatic brain injury (TBI) and other injuries.  Nine months after the accident, an MRI of the brain was interpreted by the radiologist as showing two specific T2 hyperintensities in the left frontal lobe.  NeuroQuant® volumetric analysis of the same MRI data showed markedly reduced hippocampal volume compared with an age-matched normal control group, which is consistent with atrophy due to TBI.  The hippocampal damage in this patient probably caused his posttraumatic amnesia and short-term memory impairment, which was consistent with the neuropsychological test results for this patient. 

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Ross DE, Ochs AL, Seabaugh J, Henshaw T (2012): NeuroQuant® revealed hippocampal atrophy in a patient with traumatic brain injury. Journal of Neuropsychiatry and Clinical Neurosciences 24: E33.  To view an abstract of this paper, click here.