Review of longitudinal studies of MRI brain volumetry in patients with traumatic brain injury. 

     A review of 10 studies of patients with traumatic brain injury (TBI) using MRI, volumetric measures and a longitudinal design showed a consistent pattern of brain atrophy which progressed over the months after injury.  Furthermore, atrophy correlated significantly with important clinical variables. 

     Conclusion:  In comparison with the cross-sectional design (one point in time), the longitudinal design may be preferable for understanding the progression of brain atrophy after injury and understanding its association with important clinical variables. 

Ross DE (2011): Review of longitudinal studies of MRI brain volumetry in patients with traumatic brain injury.  Brain Injury 25:1271-8.  To view the PubMed citation of this paper, click here.

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